It's perhaps the region's most iconic sign: the Citgo one in Kenmore Square in Boston. It dates from 1965, when it replaced the old Cities Service (that company created Citgo then for its marketing division). In July 2010, the 3,600-square-foot sign's LED lights replaced with more technologically advanced and environmentally-friendly ones.

Emerson College led a major renovation of the theater during the latter half of the last decade. It grandly reopened in March 2010, signage lighted up and all.

Immortalized in the opening credits of the sitcom of the same name from 1982 to 1983, the sign hangs outside the real-life Cheers Beacon Hill (formerly the Bull & Finch).

They dot the region, but we picked this one in Jamaica Plain. Both William Dawes and Paul Revere likely road past it on that fateful April 1775 night, the then-40-year-old block telling them Boston was four miles that-a way.

Say what you will about the aggressive blandness of the skyscraper itself, its "Prudential" looms higher over the region than any other sign we can think of.

The can't-miss cap to Harvard Square comes with a digital clock more than five stories above the street.

The 102-year-old park has this iconic sign above all the pennant and Series banners. (Honorable mention: the "Welcome to Fenway Park" one.)

You can't miss it going into Union Square (or out of): the mural depicting the first-ever raising of what we now know as the American flag, on July 1, 1776.

Like signage flame to tourist moths, these faux directions to various Italian areas and regions are a major draw in the North End.

The Mayflower Poultry Co.'s "Live Poultry Fresh Killed" sign has found its way onto T-shirts and hats, even underwear; and, strangely enough, into the hearts of generations of Cantabrigians.

The bright, um, shell-shaped sign is kind of Cambridge's answer to the Citgo sign in Kenmore.

The two-tiered sign for the hotel of the same name looks down on a corner of Cambridge Common.